Environment Molecules Of Emotion Book


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Molecules of Emotion by Candace B. Pert - Why do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds. In her groundbreaking book Molecules of Emotion, Candace Pert -- a neuroscientist whose extraordinary career began with her discovery of the opiate. Molecules Of Emotion by Candace Pert, , available at Book Depository with free delivery worldwide.

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Molecules of Emotion: The Science Behind Mind-Body Medicine and millions of other books are available for instant access. Molecules Of Emotion: The Science Behind Mind-Body Medicine Paperback – February 17, In her groundbreaking book Molecules of Emotion, Candace Pert. Start by marking “Molecules of Emotion: The Science Behind Mind-Body Medicine” as Want to Read: How do our thoughts and emotions affect our health? Dr. Pert describes the book as a description of her research that discovered the scientific link that proves that emotions are. Compre Molecules of Emotion: The Science Behind Mind-Body Medicine ( English Edition) de Candace B. Pert na Confira também os eBooks.

Molecules of Emotion Candace B. Pert Scribner. Candace Pert is a brilliant molecular biologist who was a key figure in the discovery of the endorphin molecule, the body's natural form of morphine. She is now widely regarded as the mother of a new field of science known as psychoneuroimmunology Smithsonian , June Her research into brain biochemistry at the National Institute of Mental Health contributed to a radically new understanding of mind and body. Now Pert and her peers are rejoining what Descartes put asunder, by looking deeply into the molecular level of life.

Though a key fitting into a lock is the standard image, a more dynamic description of this process might be two voices -- ligand and receptor -- striking the same note and producing a vibration that rings a doorbell to open the doorway to the cell.

What happens next is quite amazing. The receptor, having received a message, transmits it from the surface of the cell deep into the cell's interior, where the message can change the state of the cell dramatically. A chain reaction of biochemical events is initiated as tiny machines roar into action and, directed by the message of the ligand, begin any number of activities -- manufacturing new proteins, making decisions about cell division, opening or closing ion channels, adding or subtracting energetic chemical groups like the phosphates -- to name just a few.

In short, the life of the cell, what it is up to at any moment, is determined by which receptors are on its surface, and whether those receptors are occupied by ligands or not. On a more global scale, these minute physiological phenomena at the cellular level can translate to large changes in behavior, physical activity, even mood.

And how is all this activity organized, considering it is going on in all parts of the body and brain simultaneously? As the ligands drift by in the stream of fluid surrounding every cell, only those ligands that have molecules in exactly the right shape can bind to a particular kind of receptor. The process of binding is very selective, very specific!

In fact, we can say that binding occurs as a result of receptor specificity, meaning the receptor ignores all but the particular ligand that's made to fit it. The opiate receptor, for instance, can "receive" only those ligands that are members of the opiate group, like endorphins, morphine, or heroin. The Valium receptor can attach only to Valium and Valium-like peptides. It is this specificity of the receptors that allows for a complex system of organization and insures that everything gets to where it's supposed to be going.

Ligands are generally much smaller molecules than the receptors they bind to, and they are divided into three chemical types. The first type of ligand comprises the classical neurotransmitters, which are small molecules with such unwieldy names as acetylcholine, norepinephrine, dopamine, histamine, glycine, GABA, and serotonin. These are the smallest, simplest of molecules, generally made in the brain to carry information across the gap, or synapse, between one neuron and the next.

Many start out as simple amino acids, the building blocks of protein, and then get a few atoms added here and there. A few neurotransmitters are unmodified amino acids.

A second category of ligands is made up of steroids, which include the sex hormones testosterone, progesterone, and estrogen.

All steroids start out as cholesterol, which gets transformed by a series of biochemical steps into a specific kind of hormone. For example, enzymes in the gonads -- the testes for males, the ovaries for females -- change the cholesterol into the sex hormones, while other enzymes convert cholesterol into other kinds of steroid hormones, such as cortisol, which are secreted by the outer layer of the adrenal glands under stress.

I've saved the best for last! My favorite category of ligands by far, and the largest, constituting perhaps 95 percent of them all, are the peptides. As we shall see, these chemicals play a wide role in regulating practically all life processes, and are indeed the other half of the equation of what I call the molecules of emotion. Like receptors, peptides are made up of strings of amino acids, but I'm going to save the details about peptides until a later point in my lecture.

Meanwhile, one way to keep all this in your mind is to visualize the following: If the cell is the engine that drives all life, then the receptors are the buttons on the control panel of that engine, and a specific peptide or other kind of ligand is the finger that pushes that button and gets things started. For decades, most people thought of the brain and its extension the central nervous system primarily as an electrical communication system. It was common knowledge that the neurons, or nerve cells, which consist of a cell body with a tail-like axon and treelike dendrites, form something resembling a telephone system with trillions of miles of intricately crisscrossing wiring.

The dominance of this image in the public mind was due to the fact that we scientists had tools that allowed us to see and study the electrical brain. Only recently did we develop tools that allowed us to observe what we may now call the chemical brain. But, yet-to-be-named neuroscience was so focused, for so long, on the concept of the nervous system as an electrical network based on neuron-axon-dendrite-neurotransmitter connections, that even when we had the evidence, it was hard to grasp the idea that the ligand-receptor system represented a second nervous system, one that operated on a much longer time scale, over much greater distances.

The nerves were the classical subject of neuroscience, the route science had taken in its first explorations of the brain and central nervous system, so it was only with some disgruntlement that people could contemplate the idea of a second nervous system.

Especially difficult to accept was that this chemical-based system was one indisputably more ancient and far more basic to the organism.

Molecules Of Emotion : Why You Feel The Way You Feel

There were peptides such as endorphins, for instance, being made inside cells long before there were dendrites, axons, or even neurons -- in fact, before there were brains. Until the brain peptides were brought into focus by the discoveries of the s, most of our attention had been directed toward neurotransmitters and the jump they made from one neuron to another, across the little moat known as the synaptic cleft.

The neurotransmitters seemed to carry very basic messages, either "on" or "off," referring to whether the receiving cell discharges electricity or not. The peptides, on the other hand, while they sometimes act like neurotransmitters, swimming across the synaptic cleft, are much more likely to move through extracellular space, swept along in the blood and cerebrospinal fluid, traveling long distances and causing complex and fundamental changes in the cells whose receptors they lock onto.

This, then, was as much as we understood about the receptor and its ligands by , before researchers had actually found a drug receptor, and well before the breakthrough involving the immune system in , which used receptor theory to define a bodywide network of information and to provide a biochemical basis for the emotions.

In the wake of discoveries in the s, these receptors and their ligands have come to be seen as "information molecules" -- the basic units of a language used by cells throughout the Organism to communicate across systems such as the endocrine, neurological, gastrointestinal, and even the immune system. Overall, the musical hum of the receptors as they bind to their many ligands, often in the far-flung parts of the organism, creates an integration of structure and function that allows the organism to run smoothly, intelligently.

But I'm getting way ahead of my story. Let's take a break from the science and look at how some of these ideas developed historically. These chemical communicators, which were secreted across the synapse, or gap between neurons, also functioned in a way that could be understood by the receptor-ligand model, even though biochemistry had yet to develop a way to measure what was happening.

The chemical formula of acetylcholine, the first neurotransmitter to be discovered, was still decades away from being diagrammed when physiologist Otto Loewi did his early neurotransmitter experiments following a dream he had one night!

These first experiments, performed in , involved the action of a neurotransmitter on a frog heart. Removed from the frog and placed still beating in a large beaker, the heart slowed down dramatically when Loewi applied juice extracted from the vagal nerve to it.

The mysterious "vagusstuff" turned out to be the neurotransmitter acetylcholine. Made by the nerves, acetylcholine causes a slowing of the heartbeat and a rhythmic stimulation of the digestive muscles after eating, which together contribute to the feeling of relaxation. For both of these processes, scientists theorized that there were acetylcholine "receptor sites," some on the heart muscles, others on the digestive tract muscles, and still others on voluntary skeletal muscles, but they couldn't actually demonstrate their existence.

Early-twentieth-century theory became reality in , when Jean-Pierre Changeux addressed a pharmacology conference in England. With a dramatic flourish, the biochemist pulled from his breast pocket a tiny glass tube with a single narrow blue band across its middle.

The tube contained pure acetylcholine receptors taken from the body of an electric eel and separated from all the other eel molecules and stained blue. This was the first time a receptor had been isolated in the lab. Changeux explained how the feat had been made possible by an unholy alliance between a cobra and an electric eel, with the former supplying the venom to isolate the receptors from the latter.

In higher animals, the cobra's venom acts by entering a victim's body and diffusing to the acetylcholine receptors, including those on the diaphragm muscles, which regulate breathing. The venom blocks the access of natural acetylcholine to its receptors.

Since acetylcholine is the neurotransmitter that's responsible for muscle contraction, the resulting paralysis of the diaphragm muscles causes death by suffocation. Now, it just so happens that the densest concentration of acetylcholine receptors to be found anywhere is in the electric organ of the electric eel. Scientists had found that snake venom contained a large polypeptide, called alpha-bungero toxin, that bound specifically and irreversibly to the acetylcholine receptors in this organ that supplies the eel's jolt.

It literally stuck like glue. By introducing radioactive atoms to the toxin in the snake's venom, Changeux could follow it to where it stuck to the acetylcholine receptors of the eel's electric organ, and thereby isolate those receptors. That is how he had obtained the blue-stained substance in his test tube. The process of making a ligand hot, or radioactive, by introducing radioactive atoms into it was a brilliant innovation, but it was -- and still is -- a very tricky procedure, because the radioactive substance can destroy the ligand's ability to bind, thereby defeating the whole point of the process.

Review of ‘Molecules of Emotion’

Another major stream that had contributed to "receptorology," as we jokingly dubbed the emerging field, was the discipline of endocrinology, the study of ductless glands and their secretions. Endocrinologists, like the pharmacologists and physiologists before them, needed a way to explain how the chemical substances known as hormones acted at a distance from their sites of release on their targeted organs.

But in those days -- we're talking the s and s -- it wasn't very likely that an endocrinologist would be found talking to a pharmacologist. Each field of study occupied its own little niche and was separated from the others by strictly drawn boundaries that defined the disciplines. Those working within a given discipline were generally unaware of and uninterested in what their fellow scientists were doing elsewhere.

So people in each field kept making parallel discoveries without understanding what these discoveries had in common. In the s, endocrinologist Robert Jensen had been able to use a microscope to see estrogen receptors that had bound with radioactive estrogen he'd injected into female animals.

As predicted, the radioactive estrogen went to receptors in breast, uterine, and ovarian tissue -- all the known target organs for this female hormone. Later, estrogen receptors, as well as receptors for testosterone and progesterone, were unexpectedly found in another organ, the brain, with amazing consequences for sexual identity. But that's a later part of our story. In , endocrinologists Jesse Roth and Pedro Cuatrecasas, working on separate teams at the National Institutes of Health, were able to measure the insulin receptor by following Changeux's approach of rendering their ligand -- insulin -- radioactive.

Before, Cuatrecasas had been able to get close enough to show that insulin receptors were located on the outside surface of cells. But the new techniques for labeling substances with radioactive atoms were among the key advances that allowed for the actual measurement of the receptor, a tremendous breakthrough in this field. A NEW IDEA My own work in "receptorology" began in , in the halls of the pharmacology department of Johns Hopkins University, where I was able to earn my doctoral degree studying under two of the world's experts on insulin receptors and brain biochemistry.

At that time, the insulin receptor was the only receptor being studied with the new methods that had been developed for trapping the more slippery ligands, that is, those that, unlike the snake toxin when it bound to the acetylcholine receptor, did not stay irreversibly stuck to its receptors. No one had tried the new methods on any other drugs. But there was clearly a need to study other receptors to try to trap other kinds of ligands.

In my own field, for example, the prevailing dogma was, as I mentioned earlier, that no drug could act unless fixed. This presented an interesting challenge to neuropharmacology, the particular area of pharmacology in which I had become interested, because, theoretically, it meant that if a drug worked, there had to be a receptor, and our job should be to find it. The drugs we were studying at the time were drugs that obviously changed behavior -- I almost said consciousness, but back then nobody used the C-word, except the hippies.

Yet everyone recognized that these drugs, which included heroin, marijuana, Librium, and PCP "angel dust" , precipitated a radical change in the emotional state, that is, altered the state of consciousness of those who used them. That's why, when I began my career in the early s, such drugs were our main tool for studying the chemistry of the brain.

The problem was that our drugs were all from plants, and it was well known that once in the body these plant-derived ligands bound to receptors so briefly before exiting the body in the urine that they were difficult, if not impossible, to catch and measure on their receptors.

The challenge I would eventually make my own was to use the new methodology to trap the small morphine molecule on its receptor in a test tube -- a receptor that many people didn't even believe existed.

The proof that it did would have ramifications beyond my wildest dreams. In completely unexpected ways, the discovery of the opiate receptor would extend into every field of medicine, uniting endocrinology, neurophysiology, and immunology, and fueling a synthesis of behavior, psychology, and biology. It was a discovery that touched off a revolution, a revolution that had been quietly under way for some time -- about which more will be revealed in the future lecture sections in this book.

But now my own story must begin. One warm summer afternoon, shortly after I had been accepted into graduate school at Johns Hopkins University, I was packing for the move to Edgewood, Maryland, where I would live with my husband, Agu Pert, and our small son, Evan.

As the material objects of domestic life -- the dishes, the clothes, the iron I'd used to iron Agu's white shirts -- began to disappear into boxes, I became aware of a growing sense of panic. By the time Agu came home, I was immobilized, slumped in a chair and fighting back tears. Always the calm and steady one, he said nonchalantly, "It looks like you got a lot done.

How will I ever How would I balance the chores of my role as wife and mother with the demands of earning a Ph. I gestured pathetically at the boxes on the floor. I'll do the cooking, the cleaning, I'll make sure Evan gets to day care. Your job is to concentrate on going to school and learning psychopharmacology. About The Author. Candace B. Product Details. Scribner February Length: Raves and Reviews. Resources and Downloads.

Molecules of Emotion Trade Paperback Get a FREE e-book by joining our mailing list today! Dean Ornish, M. Highly recommended!

Rating details. Our customer reviews I Have not read his book yet however if you like a book with teeny tiny miniscule writing and the page layout crammed together this book is for u! Book ratings by Goodreads. Goodreads is the world's largest site for readers with over 50 million reviews.

We're featuring millions of their reader ratings on our book pages to help you find your new favourite book. Close X. Learn about new offers and get more deals by joining our newsletter. Sign up now. I especially like her discussion of self-honesty p. I also resonated with her discussion of focusing our intent and working through inner conflicts to increase our success and enjoyment of life.

Jun 01, Nancy rated it it was amazing Shelves: Not only was this a friendly read, but I learned a lot about the Scientific community, the politics or the system, and how it works.

When people ask me about this book, I find it hard to categorize. It's a little bit memoir, a little bit science and understanding of the human body, and a little bit personal philosophy on healing. Overall, it was both educational and uplifting and recommended to anyone who wants to explore more the connection between physiology and the mind.

May 03, Mayda Ochoa added it. Molecules of emotions A book written by a scientist, which is was also a woman, and a superb human being, who walked a long road to be able to explain scientifically why she was the way she was, and how our emotions could predestine and predict our health and even our death.

She had to fight for her knowledge in a world of men who took from her even her most precious scientific awards. This is a book, which will open your eyes to how our bodies and minds are parts of a higher existence.

Jun 03, Rebecca Bruce rated it it was amazing Recommends it for: I loved this book! What an eye-opening experience! Candace Pert, PhD discovered the opiate receptor back in the 70's. Her discovery led to the making of SSRI drugs and all kinds of mood-altering substances that she warms against.

Molecules of Emotion

Her book describes how your body is your subconscious mind, your health is a product of how you think about yourself. Taking many of the drugs on the market today alter the bodies chemistry, but that in a way that can be sustained.

Pert give advice on how to actually ch I loved this book! Pert give advice on how to actually change your molecular functioning so that pharmaceuticals are no longer needed. Pert gives a scientific explanation of the biomolecular basis of for our emotions and also the everyday ways that one can promote health in themselves.

The book is an inspiration for exploring the body-mind connection and empowering one in their quest for health and happiness.

Jun 11, Sandy rated it it was amazing. Candance Pert was on the research team that discovered how neuropeptides function in the body. Neuropeptides are the receptors that join the brain, glands, and immune system in a network of communication between brain and body. This explains how we really do feel emotion in our gut and heart. Our emotions impact our immune system. It explained to me why essential oils actually do heal.

I have quotes from the book on my website, www. May 28, Beth Haynes rated it liked it Shelves: Of particular interest because of her experience as a lab scientist working in academia and at teh NIH at the forefront of neuroscience physiology.

The main thesis of her book centers on neuropeptides as the physical basis of emotional experience. It's still considered unscientific and "alternative. Apr 05, Jack Elliott rated it it was amazing. During her post doc studies, Pert discovered the keyhole in the brain that unlocks opiates and the man she was working under took the credit.

It took awhile to get that straightened out but she finally was vindicated. She does a splendid job of explaining, in lay terms, how the mind and body are "one and the same" and do not function separately. Some fascinating science of the human mind and body. After this book she became involved in eastern spirituality and incorporated that with her brillian During her post doc studies, Pert discovered the keyhole in the brain that unlocks opiates and the man she was working under took the credit.

After this book she became involved in eastern spirituality and incorporated that with her brilliant scientific experience. If you're really interested in how the human body and mind function you will want to read this because she does an excellent job of writing to the lay reader.

Oct 03, Terry Seven rated it really liked it. I am of two minds regarding this book. On the one hand, the ideas here about the source, meaning and potential power of emotions in the body completely blew my mind. I find them compelling and plausible, and I wish there were more attention paid to these notions in modern medicine. I also did not object, as some people appear to, to learning better what it's like to be a woman and a renegade in the hyper-competitive world of medical research, or to the author's reflections on relevant personal ev I am of two minds regarding this book.

I also did not object, as some people appear to, to learning better what it's like to be a woman and a renegade in the hyper-competitive world of medical research, or to the author's reflections on relevant personal events like the death of her father.

On the other hand, the flow of the book was ridiculous. Framing the whole thing within an in-person talk was corny and confusing. Is this bragging? Or should I care for some reason? Also, many of these personal stories made me think of the author as a complete flake! It seems to me that a person so aware of the power of emotions might try harder to control her own, and have a clearer image of herself. It does seem that the geniuses of the world are like this, however: And the book itself still broke open a world of real possibilities.

I would reread it tomorrow if I had the time. There's some very interesting stuff in this book. Theories, science history, yadda yadda. It truly is fascinating stuff But it's very much mired in the administrative and, ironically, emotional, details of how scientific research gets done.

While this might be a fascinating window for some folks, since I work in the sciences, it was a little too much like my daily life to hold any interest for me, and it was certainly not in the scope of what I expected, which was a pop-science book about an i There's some very interesting stuff in this book. While this might be a fascinating window for some folks, since I work in the sciences, it was a little too much like my daily life to hold any interest for me, and it was certainly not in the scope of what I expected, which was a pop-science book about an interesting topic.

The sciences were and are a tremendously tough place for women to work, but I felt the book focused more on those issues than on the science of how emotion happens. A more appropriate if less titillating title would be "A Short History of Psychoneuroimmunology. Jan 21, Carol Manglos rated it really liked it Recommends it for: Recommended to Carol by: The oft-implied "mind-body" connection finds a pinnacle in this volume.

Review of 'Molecules of Emotion' | Arts & Culture | Smithsonian

Candace Pert started off her career with a bang, being the first scientist to isolate what we now commonly call pain receptors in the human body.

This book basically walks you through her experience into her own personal, somewhat pseudo-scientific study of a direct link between human emotions and biological function.

This is required reading for a course I'm taking, not something I pick up on preference, but I thoroughly en The oft-implied "mind-body" connection finds a pinnacle in this volume.

This is required reading for a course I'm taking, not something I pick up on preference, but I thoroughly enjoyed the book, even if I may have felt Dr.

Pert might take her conclusions a bit far sometimes: She is heading into the unknown, so she may in fact, when the chips are all cashed in, be right again. This would be a great book for medical students who like the idea of a more holistic approach to medicine.

Sep 20, Sarah rated it really liked it Shelves: I had to read this for one of my classes. It was a fascinating read.

If you are interested in why alternative medicine works, you will enjoy this book. In this book, Pert shows how the mind and the body are not separate as they have been thought to be in science for so long.

Pert uses her own life story to illustrate her scientific findings and gives recommendations for how her findings can affect the lives of her readers. At the end of her book, Pert gives recommendations for a healthy bodymind: Aug 07, Natalie rated it liked it.

Pert, of 'What The Bleep Do We Know' fame, discusses her scientific discoveries including the locating and verification of the opiate receptor in the context of her life.

The life part is interesting but gets in the way sometimes of the science, leaving me with a lot of questions about her ideas that stem from both her experiences and her science. I can't argue with the suggestions for living at the end, but I wanted more depth on the actual molecules and how they interact in the body to influ Pert, of 'What The Bleep Do We Know' fame, discusses her scientific discoveries including the locating and verification of the opiate receptor in the context of her life.

I can't argue with the suggestions for living at the end, but I wanted more depth on the actual molecules and how they interact in the body to influence or 'create,' as she claims emotion, rather than how the scientific community is an egotistical and difficult environment. Jul 16, Jim Gleason rated it it was amazing Shelves: Jun 25, Diane Mueller rated it it was amazing.

Excellent book. Really spoke to my Geek side. It was interesting to read how receptors in our body came to be understood. Then to learn how these receptors do not just live in our brains but throughout our body.

Then finally to better understand the link between our body, mind, spirit and our health and emotional state. Well worth reading. Mar 19, Karen Birdsall rated it it was amazing. This was a fascinating read, if you enjoy the science behind emotions.

Candace was a trailblazer in the field of science. I loved her determination to forge ahead even after being shunned by her mentor. He, and two others taking credit for her discovery. It's not about the molecules of emotion, it's a tedious autobiography that trickles out bits of the content that the cover and inside flap lead us to expect.

For a book about science, there are way too many exclamation points! I feel like I still need to read a book on this subject. Sep 13, Kathleen rated it really liked it. All too short, this is anyway an interesting glimpse into the thoughts and achievements of a groundbreaking neurobiologist who became interested in the mind-body connection. Dec 17, Matthew Green rated it liked it. Molecules of Emotion is not exactly what it claims to be.

Pert describes the book as a description of her research that discovered the scientific link that proves that emotions are modulated by chemicals within the body, thereby bridging the gap between mind and body. That's only part of what's happening in the book, however. Positively, Pert is an engaging writer. Her stories hook you, and her explanations of scientific details are relatively clear despite their intricacy, though she is, of Molecules of Emotion is not exactly what it claims to be.

Her stories hook you, and her explanations of scientific details are relatively clear despite their intricacy, though she is, of course, getting into more complex material than probably most of her readers will be familiar with. She presents her research and her process along the way in a way that makes it attainable and worth attending to. However, the book primarily reads like a memoir rather than an explanation of her intended point.

She spends a great deal of time talking about her life and her internal thoughts and feelings, which makes the book feel more personal and engaging, but also makes it feel scattered and disconnected. She tried to make the idea of peptides bonding to cells throughout the body as the means of communicating and producing emotion the main theme, but there was quite a bit that didn't contribute to it.

Long sections of the book were unrelated to the idea entirely. Some of those other sections were still interesting and made valuable points, such as the competitive and misogynistic culture of medical research, but it's not what the book advertised itself to be. Finally, while Pert was very exact in her microscopic research and theorizing, she was much more loose in her speculating on the macroscopic implications of that research.

I trust her lab research, but I don't trust her conclusions about it beyond the biochemistry. She increasingly pushed toward New Age ideas, particularly in the last chapter, arguing that her research proved these ideas valid, but in order to link one to the other, there were significant leaps in logic. For example, it does not follow that because the body runs on information, cause and effect are no longer useful or valid aspects of its functioning or that because information is not specific to a particular time or space, it does not belong to the material realm.

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